Across TCGA patient cohorts, NHEJ1 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NHEJ1-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and Annexin-1. Each is linked with NHEJ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHEJ1-to-partner and partner-to-NHEJ1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHEJ1→partner) and Y-score (partner→NHEJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.169	+3.189	<.001	.010	3	2
UCEC	Notch1 →	+0.257	+2.820	<.001	.035	3	1
UCEC	Annexin-1 →	+1.036	+3.169	<.001	.020	1	2
UCEC	STAT5a →	+0.480	+3.169	.028	.020	2	1
UCEC	EGFR →	-0.305	-3.169	<.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

NHEJ1 survival (RNA) · tumor vs normal (RNA) · all NHEJ1 data types