Across TCGA cell cohorts, NHEJ1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NHEJ1-associated genes across cancer lineages are BPY2, BPY2B, and BPY2C. Each is linked with NHEJ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NHEJ1-to-partner and partner-to-NHEJ1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NHEJ1→partner) and Y-score (partner→NHEJ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	BPY2 →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	BPY2B →	+0.006	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	BPY2C →	+0.006	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

NHEJ1 survival (RNA) · tumor vs normal (RNA) · all NHEJ1 data types