NGLY1

Across TCGA patient cohorts, NGLY1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,765 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible NGLY1-associated proteins across cancer lineages are TOP2B, DYNC1LI1, and TBC1D5. Each is linked with NGLY1 in more than 6 cancer types. Because this analysis shows association rather than direction, both NGLY1-to-partner and partner-to-NGLY1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NGLY1 versus TOP2B in HNSC, with a Pearson correlation of 0.32.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NGLY1→partner) and Y-score (partner→NGLY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2B →	+0.375	+0.502	<.001	<.001	3	7
OV	DYNC1LI1 →	+0.367	+0.479	<.001	<.001	3	6
OV	TBC1D5 →	+0.269	+0.463	<.001	<.001	3	5
PDAC	TOP2B_S1466 →	+0.525	+0.290	<.001	<.001	3	5
GBM	KIAA1143 →	+0.328	+0.379	.001	<.001	3	5
OV	ANKRD28 →	+0.466	+0.637	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,765 associations by consensus.

NGLY1 vs TOP2B — HNSC

Explore this scatter interactively →