NGLY1

Across TCGA patient cohorts, NGLY1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NGLY1-associated genes across cancer lineages are Heregulin, C-Raf, and Gab2. Each is linked with NGLY1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NGLY1-to-partner and partner-to-NGLY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by NGLY1-low versus NGLY1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGLY1→partner) and Y-score (partner→NGLY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Heregulin →	+0.310	+2.820	.001	.035	3	3
UCEC	C-Raf →	+0.178	+1.765	<.001	.014	3	2
UCEC	Gab2 →	+0.332	+1.415	.013	.046	3	2
UCEC	Rad50 →	-0.204	-1.765	.024	.014	3	2
UCEC	Annexin-1 →	+0.789	+2.135	<.001	.010	3	2
UCEC	ATM →	-0.688	-2.169	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Heregulin by NGLY1 expression — SKCM

Explore this box plot interactively →