NGLY1

Across TCGA cell cohorts, NGLY1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,299 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NGLY1-associated GO terms across cancer lineages are Microtubule polymerization, Regulation of metaphase/anaphase transition of cell cycle, and Regulation of centrosome cycle. Each is linked with NGLY1 in more than 11 cancer types. Because this analysis shows association rather than direction, both NGLY1-to-partner and partner-to-NGLY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule polymerization grouped by NGLY1-low versus NGLY1-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NGLY1→partner) and Y-score (partner→NGLY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Microtubule polymerization →	+0.093	+0.775	<.001	<.001	3	12
BLOOD_Lymphoma	Regulation of metaphase/anaphase transition of cell cycle →	+0.104	+0.745	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Regulation of centrosome cycle →	+0.072	+0.872	<.001	<.001	3	10
CNS	Positive regulation of pinocytosis →	+0.130	+0.707	<.001	<.001	3	10
BLOOD_Lymphoma	Microtubule polymerization or depolymerization →	+0.083	+0.808	<.001	<.001	3	10
KIDNEY	Adiponectin-activated signaling pathway →	+0.097	+0.449	.001	.007	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,299 associations by consensus.

Microtubule polymerization by NGLY1 expression — BLOOD_Lymphoma

Explore this box plot interactively →