NGLY1

Across TCGA cell cohorts, NGLY1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NGLY1-associated genes across cancer lineages are TBC1D21, WDR87, and WNT8A. Each is linked with NGLY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NGLY1-to-partner and partner-to-NGLY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D21 grouped by NGLY1-low versus NGLY1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGLY1→partner) and Y-score (partner→NGLY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D21 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	WDR87 →	+0.016	+4.353	.009	.001	3	1
LARGE_INTESTINE	WNT8A →	+0.018	+3.632	.007	.003	3	1
BLOOD_Leukemia	GPR101 →	+0.113	+4.551	<.001	.004	3	1
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TBC1D21 by NGLY1 expression — LARGE_INTESTINE

Explore this box plot interactively →