NGFR

Across TCGA pan-cancer cohorts, NGFR mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of NGFR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NGFR mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NGFR is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where NGFR tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NGFR mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.511	<.001	11	view →
PDAC	Female	II,III,IV	−1.024	<.001	9	view →
LSCC	All	All	+0.754	<.001	8	view →
LUAD	All	II,III,IV	−0.441	.010	3	view →
CCRCC	All	III,IV	−0.313	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

NGFR–HNSC

Open the HNSC breakdown →