NGF

Across TCGA patient cohorts, NGF mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NGF-associated genes across cancer lineages are MPP, CD8+ naive T-cells, and Fibroblasts. Each is linked with NGF in more than 1 cancer types. Because this analysis shows association rather than direction, both NGF-to-partner and partner-to-NGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by NGF-low versus NGF-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGF→partner) and Y-score (partner→NGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MPP →	+0.016	+2.639	.005	.020	3	1
SKCM	CD8+ naive T-cells →	-0.025	-1.887	.033	.016	3	1
COAD	Fibroblasts →	+0.025	+5.721	.044	.036	3	1
UCEC	Sebocytes →	-0.032	-3.148	.018	.020	3	1
UCEC	Th2 cells →	+0.257	+2.815	.009	.036	2	2

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

MPP by NGF expression — STAD

Explore this box plot interactively →