NGF

Across TCGA cell cohorts, NGF mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible NGF-associated genes across cancer lineages are ACER1, MYOD1, and OR1L3. Each is linked with NGF in more than 1 cancer types. Because this analysis shows association rather than direction, both NGF-to-partner and partner-to-NGF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACER1 grouped by NGF-low versus NGF-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGF→partner) and Y-score (partner→NGF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACER1 →	+0.159	+3.823	<.001	.006	3	1
BLOOD_Leukemia	MYOD1 →	+0.022	+4.922	<.001	.009	3	1
SKIN	OR1L3 →	+0.024	+5.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ACER1 by NGF expression — LARGE_INTESTINE

Explore this box plot interactively →