NGEF

Across TCGA pan-cancer cohorts, NGEF Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NGEF data layer compared with 16 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher NGEF Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated NGEF expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

OV, LIHC, and UCEC are the cancer types where NGEF Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.266	0.694	<.001	36	view →
LIHC	OS	Median	All	0.147	0.692	<.001	15	view →
UCEC	DFS	Median	All	0.910	0.617	.016	14	view →
PRAD	DFS	Median	All	0.085	0.774	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NGEF–OV (OS)

Open the OV breakdown →