NGEF

Across TCGA pan-cancer cohorts, NGEF mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NGEF data layer compared with 16 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NGEF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NGEF expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where NGEF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.463	0.223	.008	10	view →
UCEC	OS	Median	All	1.000	0.922	.041	4	view →
CCRCC	DFS	Quartile	All	0.972	0.466	.019	2	view →
GBM	DFS	Tertile	All	0.831	0.650	.027	2	view →
HNSC	DFS	Median	IV	1.000	0.413	.033	2	view →
LUAD	OS	Median	All	1.000	0.343	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NGEF–PDAC (DFS)

Open the PDAC breakdown →