NGEF

Across TCGA patient cohorts, NGEF RNA expression is significantly associated with the protein abundance of many other proteins, with 11,804 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NGEF-associated proteins across cancer lineages are NGEF_S696, NIPSNAP1, and CD2. Each is linked with NGEF in more than 4 cancer types. Because this analysis shows association rather than direction, both NGEF-to-partner and partner-to-NGEF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NGEF versus NGEF_S696 in GBM, with a Pearson correlation of 0.72.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NGEF→partner) and Y-score (partner→NGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NGEF_S696 →	+1.482	+1.451	<.001	<.001	3	5
COAD	NIPSNAP1 →	+0.391	+0.627	.001	.001	3	5
HNSC	CD2 →	-0.657	-0.844	<.001	<.001	3	4
LSCC	CD38 →	-0.658	-0.916	<.001	<.001	3	4
LSCC	DOCK10 →	-0.319	-0.834	<.001	<.001	3	4
LSCC	EVI2B_S268 →	-0.874	-0.991	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,804 associations by consensus.

NGEF vs NGEF_S696 — GBM

Explore this scatter interactively →