NGEF

Across TCGA patient cohorts, NGEF protein abundance is significantly associated with the RNA expression of many other genes, with 16,939 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible NGEF-associated genes across cancer lineages are HNF4A, NCS1, and TRIM24. Each is linked with NGEF in more than 2 cancer types. Because this analysis shows association rather than direction, both NGEF-to-partner and partner-to-NGEF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NGEF versus HNF4A in CCRCC, with a Pearson correlation of 0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGEF→partner) and Y-score (partner→NGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	HNF4A →	+1.562	+0.497	.002	.001	3	3
GBM	NCS1 →	+0.654	+0.484	<.001	<.001	3	2
HNSC	TRIM24 →	-0.708	-0.501	.001	.003	3	2
HNSC	PAQR5 →	+0.807	+0.379	.004	.006	3	2
HNSC	ZNF365 →	+0.917	+0.513	<.001	<.001	3	2
HNSC	SHISAL1 →	+0.955	+0.417	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,939 associations by consensus.

NGEF vs HNF4A — CCRCC

Explore this scatter interactively →