NGEF

Across TCGA cell cohorts, NGEF mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible NGEF-associated genes across cancer lineages are CSN3, NPSR1, and RS1. Each is linked with NGEF in more than 1 cancer types. Because this analysis shows association rather than direction, both NGEF-to-partner and partner-to-NGEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN3 grouped by NGEF-low versus NGEF-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGEF→partner) and Y-score (partner→NGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CSN3 →	+0.195	+4.011	<.001	.009	3	2
BLOOD_Leukemia	NPSR1 →	+0.023	+4.152	.001	.009	3	2
PANCREAS	RS1 →	+0.006	+4.011	<.001	.009	3	1
PANCREAS	RCVRN →	+0.093	+4.237	<.001	.006	3	1
PANCREAS	FGF23 →	+0.023	+4.237	<.001	.006	3	1
PANCREAS	OR5C1 →	+0.042	+4.237	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

CSN3 by NGEF expression — PANCREAS

Explore this box plot interactively →