NGEF

Across TCGA cell cohorts, NGEF mutation is significantly associated with the mutation status of many other genes, with 4,317 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NGEF-associated genes across cancer lineages are NFATC4, FCGBP, and EIF4G1. Each is linked with NGEF in more than 3 cancer types. Because this analysis shows association rather than direction, both NGEF-to-partner and partner-to-NGEF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFATC4 grouped by NGEF-low versus NGEF-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGEF→partner) and Y-score (partner→NGEF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	NFATC4 →	+4.117	+3.638	.002	.002	1	4
SKIN	FCGBP →	+1.947	+3.087	.005	.005	1	4
SOFT_TISSUE	EIF4G1 →	+4.502	+5.066	.007	.007	1	4
BLOOD_Leukemia	FAM83F →	+4.309	+4.560	.007	.007	1	4
BLOOD_Leukemia	LRRC36 →	+6.479	+6.479	<.001	<.001	1	4
SOFT_TISSUE	NRXN3 →	+5.502	+5.502	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,317 associations by consensus.

NFATC4 by NGEF expression — SKIN

Explore this box plot interactively →