NGDN

Across TCGA pan-cancer cohorts, NGDN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated NGDN data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher NGDN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NGDN expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

CCRCC, PDAC, and LSCC are the cancer types where NGDN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.428	0.770	<.001	62	view →
PDAC	DFS	Tertile	II,III,IV	0.302	0.584	.001	36	view →
LSCC	DFS	Quartile	All	1.000	0.898	.008	14	view →
LUAD	OS	Median	II,III,IV	0.449	0.893	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

NGDN–CCRCC (DFS)

Open the CCRCC breakdown →