NGDN

Across TCGA patient cohorts, NGDN protein abundance is significantly associated with the RNA expression of many other genes, with 20,434 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NGDN-associated genes across cancer lineages are WDR43, NEK2, and KIF14. Each is linked with NGDN in more than 7 cancer types. Because this analysis shows association rather than direction, both NGDN-to-partner and partner-to-NGDN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NGDN versus WDR43 in LSCC, with a Pearson correlation of 0.72.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGDN→partner) and Y-score (partner→NGDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR43 →	+0.851	+0.522	<.001	<.001	3	8
BRCA	NEK2 →	+1.133	+0.377	<.001	<.001	3	8
UCEC	KIF14 →	+0.948	+0.439	<.001	<.001	3	8
LUAD	GINS1 →	+0.833	+0.260	<.001	.001	3	7
GBM	CENPI →	+0.874	+0.412	<.001	<.001	3	7
GBM	ATP8B4 →	-0.625	-0.317	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,434 associations by consensus.

NGDN vs WDR43 — LSCC

Explore this scatter interactively →