NGDN

Across TCGA patient cohorts, NGDN mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NGDN-associated genes across cancer lineages are JNK_pT183_Y185, PDCD4, and Bak. Each is linked with NGDN in more than 1 cancer types. Because this analysis shows association rather than direction, both NGDN-to-partner and partner-to-NGDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by NGDN-low versus NGDN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGDN→partner) and Y-score (partner→NGDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.230	-3.584	<.001	.002	3	2
UCEC	PDCD4 →	-0.453	-2.321	.019	.006	3	2
UCEC	Bak →	+0.214	+1.874	.038	.049	3	2
UCEC	Caspase-7-cleavedD198 →	+0.695	+2.019	.004	.017	3	2
UCEC	EGFR →	-0.237	-3.000	<.001	.001	3	1
UCEC	eIF4G →	+0.280	+2.999	.028	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

JNK_pT183_Y185 by NGDN expression — UCEC

Explore this box plot interactively →