NGDN

Across TCGA cell cohorts, NGDN RNA expression is significantly associated with the go_rna of many other GO terms, with 4,264 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NGDN-associated GO terms across cancer lineages are Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Protein-RNA complex organization, and Maturation of 5.8S rRNA. Each is linked with NGDN in more than 13 cancer types. Because this analysis shows association rather than direction, both NGDN-to-partner and partner-to-NGDN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by NGDN-low versus NGDN-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NGDN→partner) and Y-score (partner→NGDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.098	+0.682	<.001	<.001	3	14
BLOOD_Lymphoma	Protein-RNA complex organization →	+0.069	+0.760	<.001	.001	3	14
SOFT_TISSUE	Maturation of 5.8S rRNA →	+0.083	+0.630	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.130	+0.831	<.001	<.001	3	13
OESOPHAGUS	Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.117	+0.974	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	RNA 5'-end processing →	+0.102	+1.183	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,264 associations by consensus.

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by NGDN expression — SKIN

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