NGB

Across TCGA patient cohorts, NGB mutation is significantly associated with the RNA expression of many other genes, with 106 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NGB-associated genes across cancer lineages are MRPS16P3, RNA5SP393, and RPLP1P10. Each is linked with NGB in more than 1 cancer types. Because this analysis shows association rather than direction, both NGB-to-partner and partner-to-NGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS16P3 grouped by NGB-low versus NGB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NGB→partner) and Y-score (partner→NGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MRPS16P3 →	+0.154	+5.315	<.001	.003	3	2
UCEC	RNA5SP393 →	+0.442	+3.351	<.001	.003	3	2
LUSC	RPLP1P10 →	+0.135	+4.110	.004	.004	3	2
LUSC	RNU1-117P →	+0.176	+4.724	<.001	.005	3	2
COAD	RNU6-13P →	+0.700	+5.893	<.001	.002	3	2
STAD	MIR5100 →	+0.170	+4.641	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 106 associations by consensus.

MRPS16P3 by NGB expression — LUAD

Explore this box plot interactively →