NGB

Across TCGA cell cohorts, NGB RNA expression is significantly associated with the go_rna of many other GO terms, with 627 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NGB-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Cytoplasmic translation, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with NGB in more than 6 cancer types. Because this analysis shows association rather than direction, both NGB-to-partner and partner-to-NGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by NGB-low versus NGB-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NGB→partner) and Y-score (partner→NGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of mRNA metabolic process →	+0.061	+1.625	.001	.005	3	7
OVARY	Cytoplasmic translation →	+0.091	+0.076	<.001	.007	3	7
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.107	+1.753	<.001	.002	3	7
LUNG_SCLC	Regulation of myoblast fusion →	+0.112	+2.038	<.001	<.001	3	6
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.118	+2.055	<.001	<.001	3	6
LUNG_SCLC	Mitochondrial electron transport, cytochrome c to oxygen →	+0.076	+1.353	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 627 associations by consensus.

Negative regulation of mRNA metabolic process by NGB expression — LUNG_SCLC

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