NFYB

Across TCGA patient cohorts, NFYB mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFYB-associated genes across cancer lineages are Notch1, PCNA, and VHL. Each is linked with NFYB in more than 1 cancer types. Because this analysis shows association rather than direction, both NFYB-to-partner and partner-to-NFYB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by NFYB-low versus NFYB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFYB→partner) and Y-score (partner→NFYB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.176	+3.321	.017	.010	1	2
UCEC	PCNA →	+0.312	+3.321	.005	.010	2	1
UCEC	VHL →	-1.148	-3.169	.001	.019	2	1
UCEC	JNK2 →	+0.250	+3.321	.016	.010	1	1
UCEC	Cyclin-B1 →	+0.700	+3.321	.017	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by NFYB expression — UCEC

Explore this box plot interactively →