NFYA

Across TCGA pan-cancer cohorts, NFYA mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NFYA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NFYA mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types NFYA is over-expressed in tumor, although a few such as HNSC and LUAD show the opposite, repressed pattern.

HNSC, CCRCC, and LUAD are the cancer types where NFYA tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NFYA mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	−0.613	<.001	11	view →
CCRCC	Male	All	+0.676	<.001	8	view →
LUAD	Female	All	−0.503	<.001	8	view →
OV	All	All	+0.742	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NFYA–HNSC

Open the HNSC breakdown →