NFXL1

Across TCGA patient cohorts, NFXL1 mutation is significantly associated with the RNA expression of many other genes, with 1,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFXL1-associated genes across cancer lineages are TMEM71, MYPOP, and MIR4695. Each is linked with NFXL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NFXL1-to-partner and partner-to-NFXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM71 grouped by NFXL1-low versus NFXL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFXL1→partner) and Y-score (partner→NFXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMEM71 →	-0.271	-2.967	.005	.001	3	3
UCEC	MYPOP →	+0.310	+2.721	.004	<.001	3	3
LUAD	MIR4695 →	+0.154	+5.930	<.001	<.001	3	3
UCEC	PACRG →	-1.052	-2.321	<.001	<.001	3	3
UCEC	TBC1D4 →	-0.631	-1.989	<.001	.001	3	3
STAD	OR11H2 →	+0.083	+3.156	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,791 associations by consensus.

TMEM71 by NFXL1 expression — UCEC

Explore this box plot interactively →