NFXL1

Across TCGA patient cohorts, NFXL1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFXL1-associated genes across cancer lineages are IGFBP2, PCNA, and PDCD4. Each is linked with NFXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFXL1-to-partner and partner-to-NFXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by NFXL1-low versus NFXL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFXL1→partner) and Y-score (partner→NFXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.637	-1.362	.005	.037	3	2
SKCM	PCNA →	+0.224	+3.000	.043	.036	3	2
UCEC	PDCD4 →	-0.454	-1.362	.006	.037	3	2
UCEC	Rab25 →	-0.297	-1.362	.011	.037	3	2
SKCM	ASNS →	+0.854	+3.000	<.001	.036	3	2
UCEC	4E-BP1_pT37_T46 →	-0.283	-2.102	.032	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

IGFBP2 by NFXL1 expression — UCEC

Explore this box plot interactively →