NFXL1

Across TCGA cell cohorts, NFXL1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NFXL1-associated genes across cancer lineages are CRYBA1, MAGEB3, and TRPC5. Each is linked with NFXL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFXL1-to-partner and partner-to-NFXL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBA1 grouped by NFXL1-low versus NFXL1-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFXL1→partner) and Y-score (partner→NFXL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CRYBA1 →	+0.258	+3.836	<.001	.004	3	2
SOFT_TISSUE	MAGEB3 →	+0.055	+4.222	<.001	.007	3	2
STOMACH	TRPC5 →	+0.006	+3.632	.001	.009	3	2
SKIN	PRG3 →	+0.016	+4.022	<.001	.006	3	2
LARGE_INTESTINE	OR52B4 →	+0.010	+3.700	<.001	.009	3	2
BONE	RBMXL3 →	+0.005	+3.672	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

CRYBA1 by NFXL1 expression — BONE

Explore this box plot interactively →