NFS1

Across TCGA pan-cancer cohorts, NFS1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NFS1 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NFS1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NFS1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, GBM, and CCRCC are the cancer types where NFS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.957	0.708	.013	14	view →
GBM	DFS	Median	All	0.823	0.540	.003	12	view →
CCRCC	DFS	Median	III,IV	0.445	0.693	.023	6	view →
UCEC	OS	Tertile	All	0.902	1.000	.018	6	view →
LUAD	OS	Tertile	All	1.000	0.726	.025	3	view →
PDAC	OS	Tertile	II,III,IV	0.751	0.924	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NFS1–LSCC (OS)

Open the LSCC breakdown →