NFS1

Across TCGA patient cohorts, NFS1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFS1-associated genes across cancer lineages are MEK1, Notch1, and p62 Lck ligand. Each is linked with NFS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFS1-to-partner and partner-to-NFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NFS1-low versus NFS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFS1→partner) and Y-score (partner→NFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.556	+3.584	.001	.002	3	1
UCEC	Notch1 →	+0.159	+2.820	.019	.035	3	1
UCEC	p62 Lck ligand →	+0.338	+2.459	.031	.020	3	1
UCEC	VHL →	-1.186	-2.459	<.001	.020	3	1
UCEC	XBP1 →	-0.231	-2.986	<.001	.035	3	1
UCEC	4E-BP1_pT37_T46 →	-0.388	-3.156	.032	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

MEK1 by NFS1 expression — UCEC

Explore this box plot interactively →