NFS1

Across TCGA cell cohorts, NFS1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NFS1-associated genes across cancer lineages are MYF5, OR10V1, and NKX2-6. Each is linked with NFS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFS1-to-partner and partner-to-NFS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF5 grouped by NFS1-low versus NFS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFS1→partner) and Y-score (partner→NFS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MYF5 →	+0.013	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10V1 →	+0.046	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KCNA4 →	+0.052	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1
BLOOD_Leukemia	HTR3D →	+0.019	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MYF5 by NFS1 expression — BLOOD_Leukemia

Explore this box plot interactively →