NFKBIZ

Across TCGA patient cohorts, NFKBIZ mutation is significantly associated with the RNA expression of many other genes, with 3,406 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBIZ-associated genes across cancer lineages are RN7SL847P, GAMTP2, and OR52A4P. Each is linked with NFKBIZ in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIZ-to-partner and partner-to-NFKBIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL847P grouped by NFKBIZ-low versus NFKBIZ-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIZ→partner) and Y-score (partner→NFKBIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RN7SL847P →	+0.260	+5.010	<.001	.009	3	2
CESC	GAMTP2 →	+0.256	+6.342	<.001	.001	3	2
LUSC	OR52A4P →	+0.154	+3.279	<.001	.009	3	2
SKCM	ST6GALNAC2P1 →	+0.026	+5.488	<.001	.001	3	2
UCEC	RNU6-1082P →	+0.146	+2.173	<.001	.005	3	2
UCEC	TRGJP2 →	+0.404	+1.599	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,406 associations by consensus.

RN7SL847P by NFKBIZ expression — CESC

Explore this box plot interactively →