NFKBIZ

Across TCGA cell cohorts, NFKBIZ mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFKBIZ-associated genes across cancer lineages are MINDY4B, GCAT, and SNU13. Each is linked with NFKBIZ in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIZ-to-partner and partner-to-NFKBIZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINDY4B grouped by NFKBIZ-low versus NFKBIZ-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIZ→partner) and Y-score (partner→NFKBIZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MINDY4B →	+0.012	+4.887	<.001	.009	3	1
LARGE_INTESTINE	GCAT →	+1.335	+3.169	<.001	.009	3	1
LARGE_INTESTINE	SNU13 →	+0.561	+3.067	<.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.559	+3.451	.004	.002	3	1
LARGE_INTESTINE	PHF5A →	+0.640	+3.364	<.001	.002	3	1
LARGE_INTESTINE	USP14 →	+0.705	+3.451	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

MINDY4B by NFKBIZ expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →