NFKBIE

Across TCGA pan-cancer cohorts, NFKBIE mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NFKBIE data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NFKBIE mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFKBIE expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where NFKBIE mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.846	1.000	.010	42	view →
LUAD	DFS	Quartile	All	0.831	0.456	.015	5	view →
CCRCC	OS	Median	All	0.773	0.916	.032	4	view →
GBM	DFS	Quartile	All	0.477	0.200	.017	4	view →
HNSC	DFS	Tertile	IV	1.000	0.883	.026	3	view →
LSCC	DFS	Quartile	III,IV	0.588	1.000	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NFKBIE–COAD (DFS)

Open the COAD breakdown →