NFKBIE

Across TCGA patient cohorts, NFKBIE mutation is significantly associated with the RNA expression of many other genes, with 476 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBIE-associated genes across cancer lineages are MIR1224, SLC6A14P3, and RN7SL105P. Each is linked with NFKBIE in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIE-to-partner and partner-to-NFKBIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1224 grouped by NFKBIE-low versus NFKBIE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIE→partner) and Y-score (partner→NFKBIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR1224 →	+0.357	+3.081	<.001	.002	3	2
DLBC	SLC6A14P3 →	+0.092	+4.491	<.001	.005	3	1
DLBC	RN7SL105P →	+0.288	+4.357	<.001	.004	3	1
CESC	CTSLP6 →	+0.045	+5.103	<.001	.008	3	1
CESC	MIR920 →	+0.509	+5.539	<.001	.004	3	1
CESC	RNA5SP369 →	+0.376	+5.539	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

MIR1224 by NFKBIE expression — UCEC

Explore this box plot interactively →