NFKBIE

Across TCGA patient cohorts, NFKBIE mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBIE-associated genes across cancer lineages are Mast cells, Class-switched memory B-cells, and Endothelial cells. Each is linked with NFKBIE in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIE-to-partner and partner-to-NFKBIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mast cells grouped by NFKBIE-low versus NFKBIE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIE→partner) and Y-score (partner→NFKBIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Mast cells →	+0.017	+2.364	.028	.019	3	1
UCEC	Class-switched memory B-cells →	-0.059	-2.892	.041	.025	2	1
UCEC	Endothelial cells →	-0.050	-3.416	.008	.005	1	1
UCEC	Erythrocytes →	+0.040	+3.459	.001	.005	1	1
UCEC	lymphatic Endothelial cells →	-0.032	-3.405	.008	.005	1	1
UCEC	mv Endothelial cells →	-0.029	-2.311	.014	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Mast cells by NFKBIE expression — UCEC

Explore this box plot interactively →