NFKBIE

Across TCGA cell cohorts, NFKBIE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,156 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NFKBIE-associated GO terms across cancer lineages are Non-canonical NF-kappaB signal transduction, Antigen processing and presentation of endogenous antigen, and Antigen processing and presentation of endogenous peptide antigen via MHC class I. Each is linked with NFKBIE in more than 13 cancer types. Because this analysis shows association rather than direction, both NFKBIE-to-partner and partner-to-NFKBIE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Non-canonical NF-kappaB signal transduction grouped by NFKBIE-low versus NFKBIE-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIE→partner) and Y-score (partner→NFKBIE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Non-canonical NF-kappaB signal transduction →	+0.108	+1.271	.001	.004	3	14
CNS	Antigen processing and presentation of endogenous antigen →	+0.213	+0.938	<.001	<.001	3	13
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.228	+0.982	<.001	<.001	3	12
CNS	Antigen processing and presentation of peptide antigen via MHC class I →	+0.170	+0.941	<.001	<.001	3	12
SOFT_TISSUE	Antigen processing and presentation of endogenous peptide antigen →	+0.234	+0.991	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Canonical NF-kappaB signal transduction →	+0.149	+1.999	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,156 associations by consensus.

Non-canonical NF-kappaB signal transduction by NFKBIE expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →