NFKBIA

Across TCGA pan-cancer cohorts, NFKBIA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NFKBIA data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NFKBIA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated NFKBIA expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where NFKBIA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.791	0.383	.001	35	view →
CCRCC	DFS	Tertile	III,IV	0.804	0.309	<.001	21	view →
LUAD	OS	Tertile	All	1.000	0.737	.010	11	view →
HNSC	DFS	Tertile	III,IV	0.865	0.635	.018	11	view →
GBM	DFS	Median	All	0.474	0.284	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NFKBIA–PDAC (OS)

Open the PDAC breakdown →