NFKBIA

Across TCGA patient cohorts, NFKBIA mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBIA-associated genes across cancer lineages are GOT2P5, BTG3P1, and RNU5E-9P. Each is linked with NFKBIA in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIA-to-partner and partner-to-NFKBIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT2P5 grouped by NFKBIA-low versus NFKBIA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIA→partner) and Y-score (partner→NFKBIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GOT2P5 →	+0.059	+7.816	<.001	.008	3	2
CESC	BTG3P1 →	+0.082	+5.669	<.001	.003	3	2
UCEC	RNU5E-9P →	+0.222	+4.148	<.001	.006	3	2
UCEC	RNU6-267P →	+0.371	+3.299	<.001	.001	3	2
LUAD	KRTAP8-2P →	+0.186	+4.730	<.001	.005	3	2
DLBC	RNU6-302P →	+0.577	+4.099	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

GOT2P5 by NFKBIA expression — SKCM

Explore this box plot interactively →