NFKBIA

Across TCGA patient cohorts, NFKBIA mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKBIA-associated genes across cancer lineages are FASN, IGFBP2, and c-Met_pY1235. Each is linked with NFKBIA in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIA-to-partner and partner-to-NFKBIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by NFKBIA-low versus NFKBIA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIA→partner) and Y-score (partner→NFKBIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.477	+3.169	.027	.020	3	1
UCEC	IGFBP2 →	-1.020	-3.169	.004	.020	3	1
UCEC	c-Met_pY1235 →	+0.084	+2.817	.040	.036	3	1
UCEC	Cyclin-E2 →	+0.204	+2.817	.027	.036	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FASN by NFKBIA expression — UCEC

Explore this box plot interactively →