NFKBIA

Across TCGA cell cohorts, NFKBIA RNA expression is significantly associated with the go_rna of many other GO terms, with 4,564 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NFKBIA-associated GO terms across cancer lineages are Positive regulation of innate immune response, Canonical NF-kappaB signal transduction, and Activation of innate immune response. Each is linked with NFKBIA in more than 13 cancer types. Because this analysis shows association rather than direction, both NFKBIA-to-partner and partner-to-NFKBIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of innate immune response grouped by NFKBIA-low versus NFKBIA-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIA→partner) and Y-score (partner→NFKBIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of innate immune response →	+0.050	+1.082	<.001	<.001	3	14
PANCREAS	Canonical NF-kappaB signal transduction →	+0.089	+1.016	.002	.005	3	13
URINARY_TRACT	Activation of innate immune response →	+0.067	+1.618	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.089	+1.300	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Response to tumor necrosis factor →	+0.068	+0.993	<.001	<.001	3	11
SOFT_TISSUE	Negative regulation of innate immune response →	+0.117	+1.090	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,564 associations by consensus.

Positive regulation of innate immune response by NFKBIA expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →