NFKBIA

Across TCGA cell cohorts, NFKBIA mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible NFKBIA-associated genes across cancer lineages are FGF6, ETNPPL, and CALHM4. Each is linked with NFKBIA in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKBIA-to-partner and partner-to-NFKBIA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by NFKBIA-low versus NFKBIA-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKBIA→partner) and Y-score (partner→NFKBIA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FGF6 →	+0.024	+3.345	<.001	.007	3	1
LARGE_INTESTINE	ETNPPL →	+0.255	+3.453	<.001	.009	3	1
LARGE_INTESTINE	CALHM4 →	+0.159	+3.878	<.001	.003	3	1
LARGE_INTESTINE	C16orf96 →	+0.707	+4.237	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF33 →	+0.076	+4.022	<.001	.006	3	1
BLOOD_Lymphoma	LCN9 →	+0.015	+4.247	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

FGF6 by NFKBIA expression — LARGE_INTESTINE

Explore this box plot interactively →