NFKB2

Across TCGA pan-cancer cohorts, NFKB2 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NFKB2 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher NFKB2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFKB2 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

COAD, GBM, and HNSC are the cancer types where NFKB2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.883	1.000	.040	24	view →
GBM	OS	Tertile	All	0.242	0.537	.001	10	view →
HNSC	OS	Quartile	III,IV	0.947	0.166	.024	10	view →
LSCC	DFS	Tertile	II,III,IV	0.576	0.887	.024	8	view →
CCRCC	OS	Median	II,III,IV	0.725	0.928	.025	3	view →
LUAD	OS	Tertile	II,III,IV	0.554	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NFKB2–COAD (DFS)

Open the COAD breakdown →