NFKB2

Across TCGA patient cohorts, NFKB2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFKB2-associated genes across cancer lineages are eIF4E, p62 Lck ligand, and p90 RSK. Each is linked with NFKB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFKB2-to-partner and partner-to-NFKB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by NFKB2-low versus NFKB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKB2→partner) and Y-score (partner→NFKB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.150	+2.584	.044	.010	3	2
UCEC	p62 Lck ligand →	+0.318	+2.000	.005	.003	3	2
UCEC	p90 RSK →	+0.209	+2.013	.002	.001	3	2
UCEC	ATM →	-0.331	-1.700	.038	.042	3	2
UCEC	14-3-3_beta →	-0.128	-3.973	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.209	-2.000	.018	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by NFKB2 expression — UCEC

Explore this box plot interactively →