NFKB1

Across TCGA pan-cancer cohorts, NFKB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NFKB1 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher NFKB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated NFKB1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where NFKB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.525	0.883	<.001	52	view →
PDAC	DFS	Tertile	All	0.557	0.310	.001	50	view →
HNSC	OS	Quartile	All	0.887	0.662	.026	15	view →
GBM	DFS	Quartile	All	0.213	0.463	.001	14	view →
LUAD	OS	Median	II,III,IV	0.457	0.815	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NFKB1–LSCC (DFS)

Open the LSCC breakdown →