NFKB1

Across TCGA cell cohorts, NFKB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,681 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NFKB1-associated GO terms across cancer lineages are Cellular response to nicotine, Canonical NF-kappaB signal transduction, and Negative regulation of vitamin D biosynthetic process. Each is linked with NFKB1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NFKB1-to-partner and partner-to-NFKB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to nicotine grouped by NFKB1-low versus NFKB1-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NFKB1→partner) and Y-score (partner→NFKB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Cellular response to nicotine →	+0.185	+1.158	<.001	.003	3	13
BONE	Canonical NF-kappaB signal transduction →	+0.096	+1.195	<.001	<.001	3	13
BONE	Negative regulation of vitamin D biosynthetic process →	+1.091	+1.098	<.001	<.001	3	12
SKIN	Response to angiotensin →	+0.107	+0.682	<.001	<.001	3	12
SKIN	Positive regulation of miRNA metabolic process →	+0.103	+0.760	.001	.004	3	12
BONE	Tumor necrosis factor-mediated signaling pathway →	+0.088	+1.331	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,681 associations by consensus.

Cellular response to nicotine by NFKB1 expression — BLOOD_Leukemia

Explore this box plot interactively →