NFIX

Across TCGA pan-cancer cohorts, NFIX mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated NFIX data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher NFIX mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated NFIX expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and COAD are the cancer types where NFIX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.844	0.680	.001	32	view →
LUAD	OS	Median	All	0.925	0.732	.001	31	view →
COAD	DFS	Tertile	All	1.000	0.918	.037	12	view →
HNSC	DFS	Quartile	II,III,IV	0.918	1.000	.032	3	view →
CCRCC	DFS	Median	III,IV	0.859	0.590	.014	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

NFIX–PDAC (DFS)

Open the PDAC breakdown →