NFIX

Across TCGA patient cohorts, NFIX mutation is significantly associated with the RNA expression of many other genes, with 1,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFIX-associated genes across cancer lineages are RNA5SP409, MTCO2P32, and OR2T33. Each is linked with NFIX in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIX-to-partner and partner-to-NFIX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP409 grouped by NFIX-low versus NFIX-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIX→partner) and Y-score (partner→NFIX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP409 →	+0.307	+7.471	<.001	.008	3	2
LUAD	MTCO2P32 →	+1.793	+5.410	<.001	.005	3	2
BLCA	OR2T33 →	+0.055	+5.018	<.001	.004	3	2
UCEC	RBBP8 →	+0.664	+2.070	<.001	.001	3	2
UCEC	OPA3 →	+0.288	+2.871	.006	.001	3	2
UCEC	MDFIC →	+0.577	+2.818	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,268 associations by consensus.

RNA5SP409 by NFIX expression — BRCA

Explore this box plot interactively →