NFIX

Across TCGA cell cohorts, NFIX mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NFIX-associated genes across cancer lineages are KRT6C, CSN2, and H2BC1. Each is linked with NFIX in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIX-to-partner and partner-to-NFIX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT6C grouped by NFIX-low versus NFIX-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIX→partner) and Y-score (partner→NFIX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KRT6C →	+0.013	+4.930	<.001	.008	3	2
LARGE_INTESTINE	CSN2 →	+0.027	+4.099	<.001	<.001	3	2
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

KRT6C by NFIX expression — SOFT_TISSUE

Explore this box plot interactively →