NFIL3

Across TCGA patient cohorts, NFIL3 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFIL3-associated genes across cancer lineages are ATM, 14-3-3_beta, and ERK2. Each is linked with NFIL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NFIL3-to-partner and partner-to-NFIL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by NFIL3-low versus NFIL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIL3→partner) and Y-score (partner→NFIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.473	-2.169	.005	.003	3	2
UCEC	14-3-3_beta →	-0.088	-3.143	.019	.018	3	1
UCEC	ERK2 →	+0.146	+1.584	.043	.034	3	1
UCEC	JNK2 →	+0.289	+3.321	<.001	<.001	3	1
UCEC	Ku80 →	+0.185	+1.428	.036	.029	3	1
UCEC	Mre11 →	-0.081	-1.765	.012	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by NFIL3 expression — UCEC

Explore this box plot interactively →