NFIC

Across TCGA pan-cancer cohorts, NFIC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated NFIC data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NFIC mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated NFIC expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where NFIC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.573	0.865	.001	37	view →
PDAC	OS	Quartile	II,III,IV	0.202	0.618	.002	16	view →
LUAD	OS	Tertile	All	0.891	0.696	.012	10	view →
LSCC	DFS	Tertile	II,III,IV	0.859	1.000	.012	8	view →
GBM	DFS	Tertile	All	0.644	0.861	.008	5	view →
UCEC	DFS	Median	III,IV	0.445	0.904	.037	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

NFIC–HNSC (OS)

Open the HNSC breakdown →