NFIC

Across TCGA patient cohorts, NFIC mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NFIC-associated genes across cancer lineages are MEK1, IGFBP2, and Ku80. Each is linked with NFIC in more than 2 cancer types. Because this analysis shows association rather than direction, both NFIC-to-partner and partner-to-NFIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by NFIC-low versus NFIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NFIC→partner) and Y-score (partner→NFIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.494	+2.807	.001	.003	3	3
UCEC	IGFBP2 →	-0.758	-2.115	.007	.019	3	1
UCEC	Ku80 →	+0.208	+1.598	.044	.044	3	1
UCEC	MEK1_p_S217_S221 →	-0.276	-2.459	.020	.019	3	1
UCEC	Notch1 →	+0.231	+3.469	<.001	.002	3	1
UCEC	p62 Lck ligand →	+0.542	+3.906	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MEK1 by NFIC expression — UCEC

Explore this box plot interactively →